Quinazoline derivatives

Details Quinazoline derivatives Quinazoline derivatives

C - Chemistry, Metallurgy

07

D

260/253

C07D 239/94 (2006.01) C07D 239/95 (2006.01) C07D 403/10 (2006.01)

Patent

CA 1169062

ABSTRACT Quinazoline derivatives of formula (I) (I) Image wherein R? and R? are C2 - C7 alkoxycarbonyl, or R? and R? are linked together to form a group of the formula: Image R2 and R3 are each hydrogen, C1 - C6 alkyl, halogen, nitro, amino, C1 - C6 alkoxy, phenoxy, C1 - C6 alkylthio, C1 - C6 alkylpiperazinyl, C1 - C18 alkanoylamino, di(C1 - C18)alkanoylamino, C3 - C9 alkoxalylamino, C4 - C8 cycloalkanecarbonylamino, C3 - C7 cycloalkyl (C1 - C6) alkanoylamino, benzamido, phenyl (C1 - C6) alkanoylamino, C1 - C6 alkanesulfonyl- amino or di(C1 - C6)alkylamino which may be substituted with hydroxy, and A1 is a group of the formula: Image Image or in which R4 is hydrogen, C1 - C6 alkyl, hydroxy, C1 - C6 alkoxy, C2 - C6 alkenyloxy, di(C1 - C6) alkyl- amino or 2,2-di(C2 - C7)alkoxycarbonylvinylamino, and R5 is C1 - C6 alkyl or C2 - C6 alkenyl, and pharma- ceutically acceptable salts thereof, have antiallergic activity.

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