Quinazoline derivatives and pharmaceutical applications therof

Details Quinazoline derivatives and pharmaceutical applications therof Quinazoline derivatives and pharmaceutical applications therof

C - Chemistry, Metallurgy

07

D

C07D 239/96 (2006.01) A61K 31/505 (2006.01) A61P 11/06 (2006.01) A61P 37/08 (2006.01) C07C 311/60 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2341357

A quinazoline derivative having formula (I), or a pharmaceutically acceptable salt thereof, which has a chymase inhibitory activity and suppresses the exacerbation of vascular permeability induced by chymase and useful as a medicament, and a pharmaceutical composition containing the same as an essential ingredient.

Cette invention, qui a trait à un dérivé de la quinazoline, représenté par la formule (I) ou à son sel, acceptable du point de vue pharmaceutique, lesquels témoignent d'une activité d'inhibition de la chymase, suppriment l'exacerbation de la perméabilité vasculaire provoquée par la chymase et se révèlent des plus utiles comme médicament, concerne également une composition pharmaceutique contenant ce dérivé ou son sel comme principal ingrédient.

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