Quinazoline derivatives as alpha-1 adrenergic antagonists

Details Quinazoline derivatives as alpha-1 adrenergic antagonists Quinazoline derivatives as alpha-1 adrenergic antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/517 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2420177

This invention relates to compounds which are generally alpha-1B adrenergic receptor antagonists and which are represented by general formula (I) wherein R1, R2, m, n, and A are as defined in the specification, or prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, the use of such compounds in the control and prevention of diseases, such as disorders of the urinary tract, sexual dysfunction, pain, or disorders of the central nervous system, and methods of preparation thereof.

L'invention concerne des composants qui sont généralement des antagonistes de récepteur adrénergiques alpha-1B et qui sont représentés par la formule générale (I) dans laquelle R?1¿, R?2¿, m, n, et A sont tels que définis dans la spécification, ou des promédicaments, des isomères individuels, des mélanges racémiques ou non racémiques d'isomères, des sels pharmaceutiquement acceptables ou des solvats de ceux-ci. L'invention concerne également des compositions pharmaceutiques contenant ces composants, l'utilisation de ces composants en vue de contrôler et de prévenir des maladies, telles que des troubles du tractus urinaire, des dysfonctionnements sexuels, des douleurs ou encore des troubles du système nerveux central et des procédés de préparation de ceux-ci.

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