Quinazoline derivatives as antiproliferative agents

Details Quinazoline derivatives as antiproliferative agents Quinazoline derivatives as antiproliferative agents

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2540019

The invention concerns quinazoline derivatives of Formula (I), wherein each of R1a, R1b, R2, R3 and a have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.

L'invention concerne des dérivés de quinazoline représentés par la formule (I), dans laquelle chacun de R?1a¿, R?1b¿, R?2¿ et R?3¿ a la signification définie dans la description; leurs procédés de préparation;, des compositions pharmaceutiques les contenant; et leur utilisation dans la production d'un médicament pour être utilisé comme agent antiprolifératif pour prévenir ou traiter des tumeurs sensibles à l'inhibition des récepteurs erbB des tyrosine kinases.

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