Quinazoline derivatives as antitumor agents

Details Quinazoline derivatives as antitumor agents Quinazoline derivatives as antitumor agents

C - Chemistry, Metallurgy

07

D

C07D 239/94 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2465100

The invention concerns quinazoline derivatives of Formula (I); wherein each of Q1, Q2, Z, R1, R2, R3, L and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.

L'invention porte sur des dérivés se la quinazoline de formule (I) dans laquelle: Q?1¿, Q?2¿, Z, R?1¿, R?2¿, R?3¿, L et m ont l'une des significations définies dans la description; sur leur procédé de préparation sur des préparations pharmaceutiques les contenant et sur leur utilisation dans la fabrication de médicaments servant à la prévention ou au traitement de tumeurs sensibles à l'inhibition des tyrosine-kinases réceptrices de la famille des erbB.

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