Quinazoline derivatives as antitumor agents

Details Quinazoline derivatives as antitumor agents Quinazoline derivatives as antitumor agents

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 403/14 (2006.01) C07D 413/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2539024

A quinazoline derivative of the formula (I): (A chemical formula should be inserted here - please see paper copy enclosed) Formula I wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blooded animal such as man.

L'invention concerne un dérivé de quinazoline de formule (I): dans laquelle les substituants sont tels que définis dans la description. Ce dérivé est utilisé dans la production d'un effet anti-prolifératif, lequel est produit seul ou partiellement par inhibition de la tyrosine kinase du récepteur erbB2 chez un animal à sang chaud, tel que l'homme.

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