Quinazoline derivatives as erbb receptor tyrosine kinases

Details Quinazoline derivatives as erbb receptor tyrosine kinases Quinazoline derivatives as erbb receptor tyrosine kinases

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2567832

The invention concerns quinazoline derivatives of the formula (I), wherein each of R1, R2, R3, R4, R5, R6, R7, X1, Q1, m and n have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.

L'invention concerne des dérivés de quinazoline représentés par la formule I dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, X?1¿, Q?1¿, m et n sont chacun tels que définis dans la description. L'invention concerne également des procédés de préparation desdits dérivés, des compositions pharmaceutiques contenant ceux-ci et leur utilisation dans la fabrication d'un médicament utilisé comme agent antiprolifératif dans la prévention ou le traitement des tumeurs sensibles à l'inhibition des tyrosine kinases du récepteur erbB.

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