Quinazoline derivatives as kinase inhibitors

Details Quinazoline derivatives as kinase inhibitors Quinazoline derivatives as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) C07D 239/94 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2426440

The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen- containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell- proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

La présente invention concerne des composés hétérocycliques contenant de l'azote et des sels de ces composés répondant aux normes pharmaceutiques, qui possèdent une activité inhibitrice sur la phosphorylation de kinases, et qui inhibent l'activité de ces kinases. Cette invention concerne aussi une technique permettant d'inhiber ces kinases et de traiter des maladies chez un mammifère par inhibition de la phosphorylation de kinases. Un aspect particulier de cette invention concerne des composés hétérocycliques contenant de l'azote et des sels de ces composés répondant aux normes pharmaceutiques qui inhibent la phosphorylation d'un récepteur du facteur de croissance dérivé des plaquettes (PDGF) de façon à gêner la croissance cellulaire anormale et la migration cellulaire, et une technique permettant de prévenir ou de traiter des maladies liées à la prolifération cellulaire telles que l'artériosclérose, l'obstruction vasculaire répétée, le cancer et la glomérulosclérose.

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