C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/517 (2006.01) A61P 25/00 (2006.01) C07D 407/14 (2006.01)
Patent
CA 2644672
The present invention if directed to certain quinazoline compounds that are PDE10 inhibitors, pharmaceutical compounds containing the same and processes for preparing the same. The invention is also directed to methods of treating diseases treatable by PDE10 enzyme such as obesity, non-insulin dependent diabetes, schizophrenia or bipolar disorder, obsessive-compulsive disorder, and the like.
La présente invention concerne certains composés de quinazoline qui sont des inhibiteurs de PDE10, des composés pharmaceutiques les contenant et des procédés de préparation de ceux-ci. La présente invention concerne également des procédés de traitement des maladies traitables par l'enzyme PDE10 telles que l'obésité, le diabète non insulinodépendant, la schizophrénie ou un trouble bipolaire, le trouble obsessionnel compulsif et analogue.
Arrington Mark P.
Conticello Richard D.
Gauss Carla
Hitchcock Stephen A.
Hopper Allen T.
Amgen Inc.
Memory Pharmaceuticals Corporation
Osler Hoskin & Harcourt Llp
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