C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/88 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 239/93 (2006.01)
Patent
CA 2718123
Compounds according to formula (I), compositions and methods are provided for modulating the activity of RAF kinases, including BRAF kinase and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by RAF kinases. Formula (I): or a pharmaceutically acceptable salt, solvate, clathrate of hydrate thereof, wherein X is O or S(O)t; Ra is O or S.
La présente invention concerne des composés représentés par la formule (I), des compositions et des méthodes utiles pour moduler l'activité des kinases RAF, y compris la kinase BRAF et pour le traitement, la prévention ou l'amélioration d'au moins un symptôme de maladie ou d'affection médiée par les kinases RAF. Cette invention porte sur un composé représenté par la formule (I): ou sur un sel, un solvate, un clathrate ou un hydrate correspondant pharmaceutiquement acceptable, dans lequel X représente O ou S(O)t; et Ra représente O ou S.
Abraham Sunny
Bhagwat Shripad
Campbell Brian T.
Chao Qi
Faraoni Raffaella
Ambit Biosciences Corporation
Goudreau Gage Dubuc
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