Quinazoline derivatives as tyrosine kinase inhibitors

Details Quinazoline derivatives as tyrosine kinase inhibitors Quinazoline derivatives as tyrosine kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2539022

A quinazoline derivative of the formula (I); wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blooded animal such as man.

La présente invention a trait à un dérivé de quinozaline de formule (I), dans laquelle les substituants sont tels que définis dans la description destinés à la production d'un effet anti-proliférant, ledit effet étant produit seul ou en partie par l'inhibition du récepteur erbB2 à activité de la tyrosine kinase chez un animal à sang chaud tel que l'homme.

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