Quinazoline derivatives as tyrosine kinase inhibitors

Details Quinazoline derivatives as tyrosine kinase inhibitors Quinazoline derivatives as tyrosine kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2538884

The invention concerns quinazoline derivatives of the Formula (I); wherein each of R1, R2, W, X1, X2, Z, a and b are as defined in the description; processes for their preparation; pharmaceutical compositions containing them and their use in the manufacture of a medicament for providing an anti- proliferative effect. The quinazoline derivatives of Formula (I) are expected to be useful in the treatment of diseases such as certain cancers mediated by erbB receptor tyrosine kinases, particularly EGFR tyrosine kinase.

L'invention concerne des dérivés de quinazoline de formule (I); dans laquelle R?1¿, R?2¿, W, X?1¿, X?2¿, Z, a et b sont tels que définis dans la description; des procédés de préparation de ceux-ci; des compositions pharmaceutiques renfermant ceux-ci et l'utilisation de ceux-ci dans la fabrication d'un médicament conférant un effet anti-prolifératif. Les dérivés de quinazoline de formule (I) devraient être utiles dans le traitement de maladies, telles que certains cancers induits par des tyrosines kinases du récepteur erbB, notamment la tyrosine kinase EGFR.

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