Quinazoline derivatives as tyrosine kinase inhibitors

C - Chemistry – Metallurgy – 07 – D

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C07D 401/12 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2599210

The invention concerns quinazoline derivatives of the Formula (I), or pharmaceutically acceptable salts thereof: I wherein each of R1, R2, R3, R4 and m are as defined in the description; processes for their preparation; pharmaceutical compositions containing them and their use in the manufacture of a medicament for providing an anti-proliferative effect. The quinazoline derivatives of Formula (I) are expected to be useful in the treatment of diseases such as certain cancers mediated by erbB receptor tyrosine kinases, particularly EGFR tyrosine kinase.

L'invention concerne des dérivés de quinazoline de formule (I) ou des sels acceptables du point de vue pharmaceutique de ceux-ci : I dans laquelle chacun de R1, R2, R3, R4 et m sont tels que définis dans la description ; des procédés pour leur préparation ; des compositions pharmaceutiques les contenant et leur utilisation dans la fabrication d'un médicament destiné à fournir un effet anti-prolifératif. On s'attend à ce que les dérivés de quinazoline de formule (I) soient utiles dans le traitement de maladies telles que certains cancers médiés par les récepteurs à activité tyrosine kinase erbB, en particulier par le récepteur à activité tyrosine kinase EGFR.

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