C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2599210
The invention concerns quinazoline derivatives of the Formula (I), or pharmaceutically acceptable salts thereof: I wherein each of R1, R2, R3, R4 and m are as defined in the description; processes for their preparation; pharmaceutical compositions containing them and their use in the manufacture of a medicament for providing an anti-proliferative effect. The quinazoline derivatives of Formula (I) are expected to be useful in the treatment of diseases such as certain cancers mediated by erbB receptor tyrosine kinases, particularly EGFR tyrosine kinase.
L'invention concerne des dérivés de quinazoline de formule (I) ou des sels acceptables du point de vue pharmaceutique de ceux-ci : I dans laquelle chacun de R1, R2, R3, R4 et m sont tels que définis dans la description ; des procédés pour leur préparation ; des compositions pharmaceutiques les contenant et leur utilisation dans la fabrication d'un médicament destiné à fournir un effet anti-prolifératif. On s'attend à ce que les dérivés de quinazoline de formule (I) soient utiles dans le traitement de maladies telles que certains cancers médiés par les récepteurs à activité tyrosine kinase erbB, en particulier par le récepteur à activité tyrosine kinase EGFR.
Halsall Christopher Thomas
Hennequin Laurent Francois Andre
Lennon Kieran
Plowright Alleyn Thomas
Storey Richard
Astrazeneca Ab
Fetherstonhaugh & Co.
LandOfFree
Quinazoline derivatives as tyrosine kinase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Quinazoline derivatives as tyrosine kinase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Quinazoline derivatives as tyrosine kinase inhibitors will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1907923