A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 239/94 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2469670
This invention relates to quinazoline derivatives that are usefulin the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such small molecules in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds. The invention further relates to small molecules that are selective for erbB2 receptor over the erbB1 receptor, wherein said erbB2 inhibitor has a range of selectivities for erbB2 over erbB1 between 50-1500.
L'invention concerne des dérivés de quinazoline utiles pour le traitement de croissance cellulaire anormale (par exemple, cancer) chez les mammifères. L'invention concerne également un procédé relatif à l'utilisation de molécules de petite taille de ce type pour le traitement de croissance cellulaire anormale chez les mammifères, en particulier les être humains, et des compositions pharmaceutiques renfermant de tels composés. L'invention concerne enfin des molécules de petite taille qui ont une action sélective vis-à-vis du récepteur erbB2 par rapport au récepteur erbB1, sachant que l'inhibiteur erbB2 présente une gamme de sélectivités vis-à-vis du récepteur erbB2 par rapport au récepteur erbB1 qui est comprise entre 50 et 1500.
Connell Richard Damian
Kath John Charles
Moyer James Dale
Pfizer Products Inc.
Sim & Mcburney
LandOfFree
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