C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/94 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2432428
The present invention relates to quinazoline derivatives of general formula (see formula I) wherein R a, R b and R c are defined as in claim 1, the tautomers, the stereoisomers and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, in particular an inhibitory effect on signal transduction mediated by tyrosine kinases, their use in the treatment of diseases, especially tumoral diseases and diseases of the lungs and airways, and the preparation thereof.
L'invention concerne des dérivés de la quinazoline de formule générale (I), dans laquelle Ra, Rb et Rc sont tels que définis dans la revendication 1, leurs tautomères, leurs stéréoisomères et leurs sels, en particulier leurs sels physiologiquement compatibles avec des acides inorganiques ou organiques, présentant des propriétés pharmacologiques précieuses, en particulier un effet d'inhibition sur la transduction de signal due à la tyrosine-kinase. L'invention concerne également l'utilisation de ces composés pour le traitement de maladies, en particulier d'affections tumorales, d'affections pulmonaires et des voies respiratoires, ainsi que leur fabrication.
Baum Anke
Blech Stefan
Himmelsbach Frank
Jung Birgit
Langkopf Elke
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Fetherstonhaugh & Co.
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