Quinazoline derivatives useful in cancer treatment

Details Quinazoline derivatives useful in cancer treatment Quinazoline derivatives useful in cancer treatment

C - Chemistry, Metallurgy

07

D

C07D 239/94 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 239/90 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2615373

The present invention provides compounds of Formula (I) (wherein R1, R2, R3, L, and X are as defined herein), or a pharmaceutically acceptable salt, solvate or ester thereof. The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases, disorders associated with activity of mutants of p53, or in causing apoptosis of cancer cells.

Composés de formule I (R1, R2, R3, L, et X sont tels que définis dans la description), y compris un sel, solvate ou ester correspondant. Egalement, compositions renfermant ces composés, utiles pour traiter des maladies liées à la prolifération cellulaire, ou des troubles associés à l'activité de mutants de p53, ou pour induire l'apoptose des cellules cancéreuses.

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