Quinazolines and related heterocyclic compounds, and their...

Details Quinazolines and related heterocyclic compounds, and their... Quinazolines and related heterocyclic compounds, and their...

C - Chemistry, Metallurgy

07

D

C07D 239/95 (2006.01) A61K 31/517 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2711272

A compound of the formula (I) wherein X is CR1 or N; Y is CR3 or N; R1, R3, R4, R5 and R6 are independently H, F, Cl, Br, I, or a hydrocarbon group which optionally contains one or more heteroatoms; R7 is a heterocyclic group including one or more N atoms; R' is R x or NR y R z wherein R x, R y and R z are each H or the same or different groups, including cyclic groups formed by R y and R z with the N atom, of up to 20 C atoms and optionally including up to 3 further heteroatoms selected from N, O and S; or a pharmaceutically acceptable salt, ester or solvate thereof.

L'invention concerne un composé de formule (I), dans laquelle X représente CR1 ou N ; Y représente CR3 ou N ; R1, R3, R4, R5 et R6 représentent indépendamment H, F, Cl, Br, I ou un groupe hydrocarboné qui contient éventuellement un ou plusieurs hétéroatomes ; R7 représente un groupe hétérocyclique incluant un ou plusieurs atomes N ; R' représente Rx ou NRyRz ; Rx, Ry et Rz représentant chacun H ou des groupes identiques ou différents, y compris des groupes cycliques formés par Ry et Rz avec l'atome N, contenant jusqu'à 20 atomes C et incluant éventuellement jusqu'à 3 hétéroatomes supplémentaires choisis parmi N, O et S ; ou un de ses sels, esters ou solvates pharmaceutiquement acceptables.

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