Quinazolinone compounds in combined modalities for improved...

A - Human Necessities – 61 – K

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A61K 31/517 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) C07D 239/88 (2006.01)

Patent

CA 2472160

The present invention provides compositions and methods for improving the effectiveness of anti-tumor treatments. The compositions of the present invention comprise quinazolinones, specifically halofuginone. In currently preferred embodiments the compositions and methods of the present invention improve the effectiveness of radiation therapy and chemotherapy, and concomitantly alleviate or prevent the damage induced by radiation therapy.

L'invention concerne des compositions et des méthodes permettant d'améliorer l'efficacité de traitements antitumoraux. Ces compositions comprennent des quinazolinones, en particulier de l'halofuginone. Dans des modes de réalisation actuellement préférés, les compositions et les méthodes de l'invention permettent d'améliorer l'efficacité d'une radiothérapie et d'une chimiothérapie, et de soulager simultanément ou de prévenir des lésions provoquées par une radiothérapie.

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