Quinazolinone compounds with reduced bioaccumulation

Details Quinazolinone compounds with reduced bioaccumulation Quinazolinone compounds with reduced bioaccumulation

A - Human Necessities

61

K

A61K 31/497 (2006.01) A01N 43/54 (2006.01) A61K 31/517 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 419/00 (2006.01)

Patent

CA 2545601

A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the formula IA and IB. IA and IB have the following structures where Z has the formula shown below and the rest of the variables are defined herein.

Cette invention se rapporte à une variété de petites molécules contenant de la guanidine capables d'agir comme agonistes de MC4-R. Ces composés sont utiles pour traiter les maladies médiées par MC4-R lorsqu'ils sont administrés à des sujets souffrant de ces maladies. Ces composés sont représentés par les formules IA et IB, dans les structures desquelles Z est représenté par la formule Z et le reste des variables est défini dans les pièces descriptives de la demande.

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