Quinazolinone-containing pharmaceutical compositions and...

A - Human Necessities – 61 – K

Patent

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A61K 31/505 (2006.01) A61K 31/4545 (2006.01)

Patent

CA 2207097

The invention provides a composition for attenuating mesangial cell proliferation, comprising an amount of a compound of formula (I) wherein: R1 is a member of the group consisting of hydrogen, halogen, nitro, benzo, lower alkyl, phenyl and lower alkoxy; R2 is a member of the group consisting of hydroxy, acetoxy, and lower alkoxy, and R3 is a member of the group consisting of hydrogen and lower alkenoxy-carbonyl; effective to attenuate mesangial cell proliferation.

Composition pour atténuer la prolifération des cellules mésangiales, renfermant un composé de formule (I) où R1 est un membre du groupe constitué d'hydrogène, d'halogène, de nitro, de benzo, d'alkyle inférieur, de phényle et d'alcoxy inférieur; R2 est un membre du groupe constitué d'hydroxy, d'acétoxy et d'alcoxy inférieur, enfin R3 est un membre du groupe constitué d'hydroxy et d'alcénoxycarbonyle inférieur; cette composition atténue efficacement la prolifération des cellules mésangiales.

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