Quinazolinone-containing pharmaceutical compositions for...

A - Human Necessities – 61 – K

Patent

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A61K 31/505 (2006.01) A61K 31/445 (2006.01) A61K 31/517 (2006.01)

Patent

CA 2228524

The invention provides a composition for attenuating neovasculatization and treating human malignancies, including a pharmaceutically effective amount of a compound of formula (I), wherein n = 1 or 2; R1 is a member of the group consisting of hydrogen, halogen, nitro, benzo, lower alkyl, phenyl and lower alkoxy; R2 is a member of the group consisting of hydroxy, acetoxy and lower alkoxy; and R3 is a member of the group consisting of hydrogen and lower alkenoxy-carbonyl; as active ingredient therein, in combination with a pharmaceutically acceptable carrier and the physiologically acceptable salts thereof. (see formula I)

Une composition, destinée à atténuer la néovascularisation et à traiter des tumeurs malignes humaines, comprend une quantité pharmacologiquement efficace d'un composé de formule (I), où R1 représente un membre du groupe consistant en hydrogène, halogène, nitro, benzo, alkyle inférieur, phényle et alkoxy inférieur; R2 représente un membre du groupe consistant en hydroxy, acétoxy, et alcoxy inférieur; et R3 représente un membre du groupe consistant en hydrogène et alkénoxy inférieur-carbonyle. Ce composé est combiné à titre d'ingrédient actif avec un vecteur pharmacologiquement acceptable.

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