Quinazolinone derivatives

Details Quinazolinone derivatives Quinazolinone derivatives

C - Chemistry, Metallurgy

07

D

C07D 239/90 (2006.01) A61K 31/517 (2006.01) A61P 25/00 (2006.01) C07D 239/88 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2431406

A quinazolinone derivatives having poly(adenosine 5'-diphaspho- ribose)polymerase (PARP) inhibotory activity represented by the formula (I), wherein R1 is optionally substituted cyclic amino groups or optionally substituted amino group, R2 is substituent, n means an integer from 0 to 4, and L is lower akkylene or lower alkenylene, or its prodrug, or their salts.

L'invention concerne des dérivés de quinazolinone ayant une activité inhibitrice de la poly(adénosine 5'-diphaspho-ribose)polymérase (PARP) représentés par la formule (I), dans laquelle R?1¿ représente des groupes amino cycliques éventuellement substitués ou un groupe amino éventuellement substitué, R?2¿ représente un substituant, n correspond à un entier relatif compris entre 0 et 4, et L représente alkylène inférieur ou alcényle inférieur, ou un promédicament ou les sels de ceux-ci.

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