Quinazolinone derivatives

Details Quinazolinone derivatives Quinazolinone derivatives

C - Chemistry, Metallurgy

07

D

C07D 239/80 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) C07D 239/82 (2006.01) C07D 401/00 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/02 (2006.01) C07D 413/06 (2006.01) C07D 453/02 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2124306

This invention is to provide quinazolinone derivatives, and their acid salts and quaternary ammonium salts, having an effect of preventing or treating diseases caused by calcium ion overload in cells, such as ischemic heart disease, ischemic cerebral disease and ischemic renal disease, and their usage. The quinazolinone derivatives are represented by the formula: (see formula 1) typically, T represents an oxygen atom; Y represents a phenyl or cyclohexyl group; R1 represents a hydrogen or chlorine atom; R2 represents a hydrogen atom; ring W represents a benzene or pyridine ring; Z represents a group of the formula: (see formulas)

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