Quinazolinone derivatives as tubulin polymerization inhibitors

Details Quinazolinone derivatives as tubulin polymerization inhibitors Quinazolinone derivatives as tubulin polymerization inhibitors

C - Chemistry, Metallurgy

07

D

C07D 239/80 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 401/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2716088

The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, n, m and X have defined meanings.

La présente invention porte sur des composés représentés par la formule (I), sur leur utilisation comme inhibiteurs de la polymérisation de la tubuline ainsi que sur des compositions pharmaceutiques comprenant lesdits composés représentés par la formule (I), dans laquelle R1, R2, R3, R4, R5, R6, n, m et X ont les significations telles que définies dans la description.

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