C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/90 (2006.01) A61K 31/517 (2006.01) A61P 29/00 (2006.01) C07C 229/56 (2006.01) C07D 239/95 (2006.01) C07D 405/04 (2006.01)
Patent
CA 2501529
The present invention relates to quinazolinones of formula (I) wherein R1 is hal; a); b); or c); X is N or CR8; R2 is hal; nitro; C1-C6alkylcarbonyl; C1- C6alkyl or C3-C6cycloalkyl; R3 is C1-C6alkyl; C1-C6alkoxy or amino; and wherein the further radicals have the meanings as defined in the specification, which compounds exhibit human vanilloid antagonistic activity; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
L'invention concerne des quinazolinones de formule (I) dans laquelle R?1¿ désigne hal; a); b); ou c); X désigne N ou CR?8¿; R?2¿ désigne hal; nitro; un alkylcarbonyle en C¿1?-C¿6?; un alkyle en C¿1?-C¿6 ?ou un cycloalkyle en C¿3?-C¿6?; R?3¿ désigne un alkyle en C¿1?-C¿6?; un alcoxy en C¿1?-C¿6 ?ou un amino; et dans laquelle les autres radicaux ont les désignations spécifiées dans la description, lesdits composés présentant une acitivité antagoniste vanilloïde humaine. L'invention concerne en outre des procédés de production de ces composés, leur utilisation comme produits pharmaceutiques, ainsi que des compositions pharmaceutiques les renfermant.
Culshaw Andrew James
Dziadulewicz Edward Karol
Hallett Allan
Hart Terance William
Fetherstonhaugh & Co.
Novartis Ag
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