Quinazolinone pharmaceuticals and use thereof

Details Quinazolinone pharmaceuticals and use thereof Quinazolinone pharmaceuticals and use thereof

A - Human Necessities

61

K

A61K 31/505 (2006.01) A61K 31/517 (2006.01)

Patent

CA 2198875

The invention provides a pharmaceutical composition for preventing restenosis by the inhibition of vascular smooth muscle cell proliferation, comprising a compound of formula I: Image wherein: n=1 or 2 R1 is a member of the group consisting of hydrogen, halogen, nitro, benzo, lower alkyl, phenyl and lower alkoxy; R2 is a member of the group consisting of hydroxy, acetoxy, and lower alkoxy, and R3 is a member of the group consisting of hydrogen and lower alkenoxy-carbonyl as active ingredient therein, or a physiologically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier.

L'invention concerne une composition pharmaceutique conçue pour empêcher la resténose par inhibition de la prolifération des cellules des muscles lisses, qui comprend un composé de la formule (I) dans lequel: R1 est un membre du groupe constitué d'hydrogène, halogène, nitro, benzo, alkyle inférieur, phényl et alcoxyle inférieur; R2 est un membre du groupe constitué d'hydroxy, acétoxy, et alcoxyle inférieur, et R3 est un membre du groupe constitué d'hydrogène et d'alkénoxy-carbonyle inférieur agissant comme principe actif en association avec un véhicule acceptable sur le plan pharmaceutique.

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