Quinazolinone, quinolone and related analogs as sirtuin...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/12 (2006.01) A61K 31/4375 (2006.01) A61K 31/439 (2006.01) A61K 31/4709 (2006.01) A61K 31/497 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01) C07D 239/91 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 453/02 (2006.01)

Patent

CA 2738809

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

La présente invention concerne de nouveaux composés modulateurs de sirtuine et des procédés dutilisation de ceux-ci. Les composés modulateurs de sirtuine peuvent être utilisés pour augmenter la durée de vie dune cellule, et traiter et/ou prévenir une grande variété de maladies et de troubles comprenant, par exemple, des maladies ou troubles associés au vieillissement ou au stress, le diabète, lobésité, des maladies neurodégénératives, une maladie cardiovasculaire, des troubles de coagulation sanguine, linflammation, le cancer, et/ou les bouffées congestives ainsi que des maladies ou troubles qui bénéficieraient dune activité mitochondriale augmentée. La présente invention concerne en outre des compositions comprenant un composé modulateur de sirtuine en combinaison avec un autre agent thérapeutique.

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