Quinazolinones as inhibitors of human phosphatidylinositol...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 487/04 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2566609

Compounds that inhibit PI3K.delta. activity, including compounds that selectively inhibit PI3K.delta. activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K.delta.) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3K.delta. plays a role in leukocyte function, using the compounds also are disclosed.

L'invention concerne des composés inhibant l'activité de la PI3K?, notamment des composés inhibant de manière sélective l'activité de la PI3K?. L'invention concerne également des procédés d'inhibition de l'activité de l'isoforme de la phosphatidylinositol 3-kinase delta (PI3K?), ainsi que des méthodes de traitement de maladies telles que les troubles immunitaires et les inflammations, dans lesquelles la PI3K? est impliquée dans la fonction leucocytaire, au moyen desdits composés.

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