Quinazolone derivatives as alpha 1a/b adrenergic receptor...

Details Quinazolone derivatives as alpha 1a/b adrenergic receptor... Quinazolone derivatives as alpha 1a/b adrenergic receptor...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/549 (2006.01) A61P 13/08 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2432578

This invention relates to compounds which are generally alpha-1A/B adrenoceptor antagonists and which are represented by formula (I) (see formula I) wherein Z is -C(O)- or -S(O)2-, X is carbon or nitrogen, Y is carbon, and X-Y considered together are two adjoining atoms of the ring A, said ring being a fused aromatise ring of five to six atoms per ring optionally incorporating one to two heteroatoms per ring; chosen from N, O, or S; and the other substituents are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their preparation and their use as therapeutic agents.

L'invention concerne des composés qui sont généralement des antagonistes de récepteur alpha-1A/B adrénergique et qui sont représentés par la formule (I) dans laquelle Z représente un groupe -C(O)- ou -S(O)2-, X représente un carbone ou un azote, Y représente un carbone, et X-Y pris ensemble représentent deux atomes adjacents du cycle A, ce cycle étant un cycle aromatique fusionné comprenant de cinq à six atomes par cycle, contenant éventuellement un ou deux hétéroatomes par cycle choisis parmi N, O, ou S, les autres substituants étant définis dans la description. L'invention concerne aussi des isomères individuels, racémiques ou des mélanges non racémiques d'isomères, des sels ou des solvates de ces composés, acceptables sur le plan pharmaceutique. Elle concerne enfin des compositions pharmaceutiques contenant de tels composés, des procédés pour leur préparation et leur utilisation comme agents thérapeutiques.

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