Quinobenzoxazine, quinobenzothiazine, and pyrido-acridine...

Details Quinobenzoxazine, quinobenzothiazine, and pyrido-acridine... Quinobenzoxazine, quinobenzothiazine, and pyrido-acridine...

C - Chemistry, Metallurgy

07

D

C07D 498/06 (2006.01) A61K 31/47 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 38/04 (2006.01) C07D 455/03 (2006.01) C07D 498/16 (2006.01) C07D 513/06 (2006.01) C07K 5/04 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2099609

2099609 9203136 PCTABS00010 Quinobenzoxazine, quinobenzothiazines, and pyrido-acridine derivatives of formula (I), as well as the pharmaceutically acceptable salts, esters, amides and prodrugs thereof are disclosed, wherein R1 is hydrogen or a carboxy-protecting group, R2 and R3 are substituents, A is oxygen, sulfur, or carbon, Z is a halogen or a nitrogen-containing group, X is hydrogen, halogen or alkyl, and W is hydrogen, alkyl, amino or halogen. The compounds have potent antineoplastic activity.

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