C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/60 (2006.01) A61K 31/47 (2006.01) A61K 31/661 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) C07D 215/56 (2006.01)
Patent
CA 2634113
The present invention relates to prodrugs of modulators of ABC transporters, particularly, CFTR modula-tors, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.Formula (I).
La présente invention concerne des promédicaments de modulateurs de transporteurs ABC, en particulier, des modulateurs CFTR, des compositions de ceux-ci, et des procédés connexes. La présente invention concerne également des procédés de traitement de maladies induites par des transporteurs ABC utilisant de tels modulateurs.
Binch Hayley
Grootenhuis Peter D. J.
Hadida Ruah Sara
Hazlewood Anna
Zhou Jinglan
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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