Quinoline-3-acetic acid derivative, process for production...

Details Quinoline-3-acetic acid derivative, process for production... Quinoline-3-acetic acid derivative, process for production...

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2131370

Abstract A quinoline-3-acetic acid derivative of the formula Image (I) wherein R1, R2 and R3 are the same or different and each is a hydrogen atom or a halogen atom, R4 is a hydrogen atom, a halogen atom or a substituted or unsubstituted lower alkyl, R5 is an optionally esterified carboxyl and the broken line means an optional presence of a double bond, and a pharmaceutically acceptable salt thereof. The novel compound of the formula (I) and a pharmaceutically acceptable salt thereof of the present invention have an aldose reductase inhibitory activity in mammals inclusive of human and are highly safe. Accordingly, they are useful as pharmaceutical compositions for the treatment of the complications of diabetes, such as faulty union of corneal injury, cataract, neurosis, retinopathy and nephropathy, particularly cataract and neurosis. 4 2

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