Quinoline and pyridine anchors for hmg-coa reductase inhibitors

Details Quinoline and pyridine anchors for hmg-coa reductase inhibitors Quinoline and pyridine anchors for hmg-coa reductase inhibitors

C - Chemistry, Metallurgy

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C07F 9/576 (2006.01) A61K 31/675 (2006.01) C07D 213/55 (2006.01) C07D 213/89 (2006.01) C07D 221/08 (2006.01) C07D 221/16 (2006.01) C07F 9/58 (2006.01) C07F 9/60 (2006.01) C07F 9/6558 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2036417

HX16c Abstract QUINOLINE AND PYRIDINE ANCHORS FOR HMG-CoA REDUCTASE INHIBITORS Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypo- cholesterolemic agents are provided which have a quinoline or a pyridine anchor attached by means of a linker to a binding domain sidechain, which compounds inhibit the enzyme 3-hydroxy-3-methyl- glutaryl-coenzyme A reductase.

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