Quinoline compounds for use in mch receptor related disorders

A - Human Necessities – 61 – K

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Details

A61K 31/519 (2006.01) A61K 31/435 (2006.01) A61K 31/4375 (2006.01) A61K 31/4709 (2006.01) A61K 31/4985 (2006.01) A61K 31/5025 (2006.01) A61K 31/506 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2508681

The present invention relates to the use of quinoline compounds for the preparation of a pharmaceutical and/or a cosmetic composition for the treatment, prophylaxis and/or diagnosis of a condition caused by or involving a melanin-concentrating hormone. The invention also relates to novel quinoline compounds per se. The quinoline compounds have been found to interact with a melanin-concentrating hormone receptor, a MCH receptor. The compounds have modulating activity on the MCH receptor such as e.g. antagonistic, agonistic or allosteric activity and are useful for medicinal or cosmetic purposes such as, e.g. in the treatment or prevention of feeding disorders like obesity, metabolic syndrome, Type II diabetes, bulimia, etc. or in the treatment or prevention of depression.

La présente invention se rapporte à l'utilisation de composés de la quinoline pour préparer une composition pharmaceutique et/ou cosmétique destinée au traitement, à la prophylaxie et/ou au diagnostic d'un trouble causé par une hormone de mélano-concentration ou lié à cette dernière. L'invention concerne également lesdits nouveaux composés de la quinoline eux-mêmes. L'on a pu établir que les composés de la quinoline selon l'invention interagissaient avec un récepteur de l'hormone de mélano-concentration (récepteur MCH). Les composés selon l'invention possèdent une activité modulatrice sur le récepteur MCH, telle qu'une activité antagoniste, agoniste ou allostérique, et peuvent être avantageusement utilisés à des fins médicales ou cosmétiques, par exemple pour traiter ou prévenir les troubles de l'alimentation tels que l'obésité, le syndrome métabolique, le diabète de type II, la boulimie, etc., ou pour traiter ou prévenir la dépression.

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