Quinoline derivative

Details Quinoline derivative Quinoline derivative

C - Chemistry, Metallurgy

07

D

C07D 451/12 (2006.01) C07D 451/04 (2006.01) C07D 451/14 (2006.01)

Patent

CA 2097815

Quinoline derivatives represented by formula (I): (see formula I) wherein A-B-D represents -C(COO-Y)=CH-C(OR)= (Wherein Y represents 8-methyl-8-azabicyclo[3.2.1]oct-3-yl group and R represents alkyl) or -C(OH)=C(COX-Y)-CH=(wherein X represents -O- or -NH-; and Y has the same meaning as described above), or a pharmaceutically acceptable salt thereof, possess potent 5HT3 antagonizing activity and are useful as anti-emetic agents.

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