Quinoline derivatives

Details Quinoline derivatives Quinoline derivatives

C - Chemistry, Metallurgy

07

D

260/287, 260/277

C07D 215/36 (2006.01) C07C 233/11 (2006.01) C07D 211/42 (2006.01) C07D 215/18 (2006.01) C07D 277/28 (2006.01) C07D 333/24 (2006.01) C07D 401/00 (2006.01) C07F 7/08 (2006.01)

Patent

CA 1189077

ABSTRACT Compounds of the formula: Image wherein A stands for the radical -(CH2)2- which may bear one or two defined substituents; R1 stands for a (3-4C)alkyl or cyclopropyl radical, or a phenyl radical which may optionally bear one or two defined substituents, or a heteroaryl radical of five or six ring atoms which may optionally bear a (1-3C)alkyl substituent; R2 and R3 stand for hydrogen or a (1-2C)alkyl radical, or R2 stands for a (2-4C)alkylene radical which is linked to one of the carbon atoms forming the two-carbon-atom- backbone of A so as to form, together with the adjacent nitrogen atom, a pyrrolidinyl or piperidyl radical; and one of R4 and R5 stands for hydrogen, and the other stands for hydrogen, a halogen atom or a (1-3C)alkyl or (1-3C)alkoxy radical; and acid-addition salts thereof. Processes for the manufacture of said compounds. Pharmaceutical compositions comprising one of said compounds and a pharmaceutical diluent or carrier. The compounds are 5-hydroxytryptamine antagonists.

404277

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