Quinoline derivatives

Details Quinoline derivatives Quinoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/02 (2006.01) A61K 31/435 (2006.01) C07D 219/06 (2006.01) C07D 221/16 (2006.01) C07D 401/06 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2053640

Quinoline derivatives of the formula, Image wherein >A~ represents a group >N-(CH2)n- , >C=, >C=CH(CH2)n-, or >CH(CH2)n-, wherein n is an integer of 0-7; Y represents a group >C=O or >CHOH, R1 is a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group, R2 is a hydrogen atom, a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, a phenyl group which may have a substituent, a phenoxy group, an alkanoyloxy group, or an amino group which may have a substituent, R3 is a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group, and m is an integer of 1-3. The compounds and their salts exhibit a superior anti- acetylcholinesterase activity with no side effects and are effective for the prevention or cure of senile dementia or memory disturbance.

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