Quinoline derivatives

Details Quinoline derivatives Quinoline derivatives

C - Chemistry, Metallurgy

07

D

167/227, 260/277

C07D 221/10 (2006.01) A61K 31/47 (2006.01) C07D 401/06 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2011640

RAN 4085/11 Abstract The compounds of the formula Image I wherein R1 signifies hydrogen, lower-alkyl, which is optionally substituted by hydroxy, lower-alkoxy, cyano, halogen, lower-alkoxycarbonyl, aminocarbonyl, ubctituted benzoyl or substituted .alpha.-hydroxybenzyl, lower-alkenyl, cycloalkyl, cycloalkyl-lower-alkyl, heteroaryl-lower-alkyl or aryl-lower-alkyl, which is optionally substituted by hydroxy, lower-alkoxy, lower-alkyl or halogen, and R2 signifies hydrogen or lower-alkanoyl, in the form of the racemates and the optical antipodes as well as pharmaceutically usable acid addition salts thereof are active as selective, presynaptically-acting dopamine receptor agonists and are accordingly suitable for the control or prevention of central nervous system illnesses, especially for the control or prevention of psychotic disorders such as chronic schizophrenia. They can be manufactured according to various methods which are known per se.

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