C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/56 (2006.01) A61K 31/47 (2006.01) C07D 215/22 (2006.01)
Patent
CA 2329788
The invention relates to compounds of general formula (I) wherein R is selected from ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec.-butyl and a11y1; R4 is selected from hydrogen and pharmaceutically acceptable inorganic and organic cations; R5 is selected from methyl, ethyl, n-propyl, iso-propyl, methoxy, ethoxy, chloro, bromo, CF3, and OCHxFy; wherein x - O - 2, y - 1 - 3 with the proviso that x + y = 3; R6 is hydrogen; or R5 and R6 taken together are methylenedioxy; and any tautomer thereof. The invention also relates to pharmaceutical compositions containing a compound of general formula (I) together with a pharmaceutically acceptable carrier. Included are also processes for the preparation of the compounds of formula (I), as well as methods of treating mammals suffering from diseases resulting from autommunity and pathological inflammation by administrering a compound having formula (I) to said mammal.
L'invention concerne des composés de la formule générale (I) où R est sélectionné parmi l'éthyle, n-propyle, iso-propyle, n-butyle, iso-butyle, sec.-butyle et allyle; R4 est choisi parmi l'hydrogène et des cations organiques et anorganiques pharmaceutiquement acceptables ; R5 est choisi parmi le méthyle, éthyle, n-propyle, iso-propyle, métoxy, éthoxy, chlore, brome, CF3 et OCHxFy; x = 0 - 2, y = 1 - 3 à condition que x + y = 3 ; R6 représente de l'hydrogène ; Ou R5 et R6 ensemble représentent du méthylèndioxy ; et n'importe quel de ses tautomère. L'invention concerne également des compositions pharmaceutiques contenant un composé de la formule générale (I) et un excipient pharmaceutiquement acceptable. L'invention concerne des procédés de préparation des composés de la formule (I) ainsi que des procédés de traitement de mammifères souffrant de maladies résultant d'une inflammation auto-immune et pathologique par administration audit mammifère d'un composé ayant la formule (I).
Bjork Anders
Fex Tomas
Hedlund Gunnar
Jonsson Stig
Active Biotech Ab
Smart & Biggar
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