Quinoline derivatives and quinazoline derivatives

Details Quinoline derivatives and quinazoline derivatives Quinoline derivatives and quinazoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 215/22 (2006.01) A61K 31/47 (2006.01) A61K 31/4725 (2006.01) A61K 31/496 (2006.01) A61K 31/517 (2006.01) A61K 31/5355 (2006.01) A61P 35/00 (2006.01) C07D 215/233 (2006.01) C07D 239/88 (2006.01) C07D 239/96 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2361057

An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: (see formula I) wherein X and Z each independently represent CH or N; R1 to R3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R4 represents H; R5 to R8 represent H, halogen, alkyl, alkoxy, alkylthio, nitro, or amino, provided that R5 to R8 do not simultaneously represent H; R9 and R10 represent H, alkyl, or alkylcarbonyl; and R11 represents alkyl, alkenyl, alkynyl, or aralkyl.

La présente invention concerne des composés ayant une action antitumorale et n'induisant pas de modification morphologique au niveau des cellules. En l'occurrence, cette invention concerne ces composés de formule générale (I), leurs sels acceptables sur le plan pharmaceutique et leurs solvates, ainsi que des compositions médicamenteuses contenant également (I), où X et Z représentent chacun CH ou N; R?1-3¿ représentent chacun H, éventuellement alcoxy substitué, etc.; R?4¿ représente H; R?5-8¿ représentent chacun H, halogéno, alkyle, alcoxy, alkylthio, nitro ou amino, sous réserve que la totalité de R?5-8¿ ne représente pas H simultanément; R?9¿ et R?10¿ représentent chacun H, alkyle ou alkylcarbonyle; et R?11¿ représente alkyle, alcynyle, alkynyle ou aralkyle.

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