C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/4709 (2006.01) A61K 31/517 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2445333
An object of the present invention is to provide compounds having potent antitumor activity. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: (see formula I) wherein X and Z represent CH or N; Y represents O or S; R1, R2, and R3 represent H, alkoxy or the like; R4 represents H; R5, R6, R7, and R8 represent H, halogen, alkoxy or the like; R9 and R10 represent H, alkyl or the like; and R11 represents optionally substituted azolyl.
L'invention concerne un composé ayant une forte activité antitumorale. C'est un composé représenté par la formule (I) ou un sel ou solvate pharmaceutiquement acceptable de ce dernier. Dans la formule (I), X et Z représentent respectivement CH ou azote ; Y représente oxygène ou soufre ; R?1¿, R?2¿ et R?3¿ représentent respectivement hydrogène, alcoxy etc. ; R4 représente hydrogène ; R?5¿, R?6¿, R?7¿ et R?8¿ représentent respectivement hydrogène, halogène, alcoxy etc. ; R?9¿ et R?10¿ représentent respectivement hydrogène, alkyle etc. ; et R?11¿ représentent un azolyle éventuellement substitué.
Fujiwara Yasunari
Hasegawa Kazumasa
Isoe Toshiyuki
Kubo Kazuo
Nagao Rika
Kirin Beer Kabushiki Kaisha
Kyowa Hakko Kirin Co. Ltd.
Smart & Biggar
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