Quinoline derivatives and use as antitumor agents

Details Quinoline derivatives and use as antitumor agents Quinoline derivatives and use as antitumor agents

C - Chemistry, Metallurgy

07

D

C07D 215/22 (2006.01) A61K 31/47 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2621988

The invention provides compounds of formula I as described herein wherein Y is F, Cl or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof.

L'invention porte sur un composé de formule (I) dans laquelle: Y est F, Cl ou Br; ou l'un de ses sels pharmacocompatibles efficaces en tant qu'agents antitumoraux. L'invention porte également sur des préparations pharmaceutiques comportant le composé de formule (I) ou l'un de ses sels, sur des intermédiaires de production du composé de formule (I) et sur des méthodes thérapeutiques consistant à administrer le composé de formule (I) ou l'un de ses sels à un mammifère le nécessitant.

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