Quinoline derivatives as pi3 kinase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/14 (2006.01) A61K 31/4709 (2006.01) A61K 31/495 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 401/10 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01) C07D 493/04 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2686016

Invented is a method of inhibiting the activity/function of PB kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative discase, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.

Procédé d'inhibition d'activité/de fonction de PI3 kinases reposant sur l'utilisation de dérivés de quinoline. Également, procédé de traitement, par administration de dérivés de quinoline, d'une ou plusieurs maladies pouvant être: troubles autoimmunes, maladies inflammatoires, cardio-vasculaires, neurodégénératives, allergie, asthme, pancréatite, défaillance de plusieurs organes, maladies rénales, agrégation plaquettaire, cancer, motilité du sperme, rejet de transplant, rejet de greffon, et lésions pulmonaires.

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