Quinoline derivatives as probes for the diagnosis of...

G - Physics – 01 – N

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G01N 33/68 (2006.01) A61B 6/00 (2006.01) A61K 31/47 (2006.01) A61K 31/473 (2006.01) A61K 51/04 (2006.01) A61P 25/28 (2006.01) C07D 215/00 (2006.01) C07D 215/52 (2006.01) G01N 23/00 (2006.01)

Patent

CA 2465554

The present invention provides compounds, or salts or solvates thereof, which can be used as probes for the imaging diagnosis of diseases in which tau protein accumulates, and compositions and kits comprising such compounds, or salts or solvates thereof. The present invention also provides a method for staining neurofibrillary tangles in brain samples, and a pharmaceutical composition for the treatment and/or prophylaxis of a disease in which .beta.-sheet structure is the cause or possible cause.

Cette invention concerne un composé qui peut servir de sonde pour le diagnostic par imagerie d'une maladie associée à une accumulation de la protéine tau, le sel ou un solvate de ce composé, et une composition ou une trousse contenant ceux-ci. L'invention concerne également un procédé de coloration des dégénérescences neurofibrillaires dans les matières cérébrales, et une composition pharmaceutique destinée à prévenir ou à traiter une maladie causée entièrement ou partiellement par la structure de feuillet beta des protéines.

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