Quinoline intermediates of receptor tyrosine kinase...

Details Quinoline intermediates of receptor tyrosine kinase... Quinoline intermediates of receptor tyrosine kinase...

C - Chemistry, Metallurgy

07

D

C07D 215/54 (2006.01) C07D 295/14 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2553729

This invention is directed to methods of preparing 4-substituted quinoline compounds as intermediates in the manufacture of receptor tyrosine kinase inhibitors and intermediate compounds used in the methods thereof, wherein the 4-substituted quinoline compound has the general formula (I); and wherein substitutions at LG~, PG, A, G, R1 and R4 are set forth in the specification.

L'invention porte sur des procédés de préparation de composés de quinoléine substitués en 4 comme intermédiaires destinés à la fabrication des inhibiteurs des récepteurs de tyrosine kinase et sur des composés intermédiaires faisant appel auxdits procédés. Le composé de quinoléine substitué en 4 répond à la formule générale (I) ; dont les substitutions en LG , PG, A, G, R¿1? et R¿4? sont énoncées dans la spécification.

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