Quinoline or quinazoline derivatives as anti-inflammatory...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 215/54 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 215/60 (2006.01) C07D 239/74 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 475/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2184392

This invention provides an anti-inflammatory agent, particularly an agent for treating arthritis, containing a quinoline or quinazoline derivative or a salt thereof of formula (I), wherein Y is a nitrogen atom or C-G in which G is an optionally esterified carboxyl group; R1 and R2 are each independently a hydrogen atom, optionally substituted hydrocarbon group or optionally substituted heterocyclic group, or R1 and R2 are linked together to form a saturated ring; each of the ring A and ring B may optionally be substituted; n is an integer of 1 to 4; and k is 0 or 1. This invention also provides a novel quinoline or quinazoline derivative having anti-inflammatory activity.

L'invention se rapporte à un anti-inflammatoire, plus particulièrement destiné au traitement de l'arthrite, contenant un dérivé de quinoline ou de quinazoline, ou un sel de ce dérivé, lequel répond à la formule (I), dans laquelle Y représente un atome d'azote ou C-G, G représentant un groupe carboxyle éventuellement estérifié; R<1> et R<2> représentent chacun indépendamment un atome d'hydrogène, un groupe hydrocarbure éventuellement substitué ou un groupe hétérocyclique éventuellement substitué, ou bien R<1> et R<2> forment ensemble un noyau saturé; chacun des noyaux A et B peut éventuellement être substitué; n représente un nombre entier compris entre 1 et 4 inclus; et k vaut 0 ou 1. L'invention se rapporte également à de nouveaux dérivés de quinoline ou de quinazoline présentant une activité anti-inflammatoire.

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