Quinolinecarboxylic acid derivative and process for...

C - Chemistry – Metallurgy – 12 – P

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C12P 41/00 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/54 (2006.01) C07D 215/56 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2152791

The invention relates to a quinolinecarboxylic acid derivative of the following general formula [I] or a pharmaceutically acceptable salt of [I]. Image [ I ] wherein Z represents substituted or unsubstituted cyclic amino or phenyl; A represents >C=CH2 or >CHR1 (R1 : fluoroalkyl); R2 represents hydrogen, alkyl, alkoxy, amino, or halogen; and R3 represents hydrogen or alkyl. The compound of the invention is effective in various infectious diseases and is particularly useful for the treatment of infections caused by gram-positive bacteria including methicillin-resistant Staphylococcus aureus and new quinolone-resistant, methicillin-resistant Staphylococcus aureus.

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