C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/495 (2006.01) A61P 35/00 (2006.01) C07D 215/22 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2587642
Selected compounds of Formula (I) are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases such as cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes. R - X - W - A - Y - R Formula (I) wherein R is X is O, S, NR2 or CR3R4 W is an substituted or unsubstituted aryl or substituted or unsubstituted 5- or 6- membered heteroaryl.
La présente invention a trait à des composés sélectionnés efficaces pour la prévention et le traitement de maladies, telles que des maladies impliquant le facteur de croissance des hépatocytes (HGF). L'invention a également trait à de nouveaux composés, analogues, prodrogues et sels pharmaceutiquement acceptables de ceux-ci, à des compositions pharmaceutiques et à des procédés pour la prévention et le traitement de maladies et d'autres troubles ou conditions comprenant le cancer et analogue. La présente invention a trait en outre à des procédés pour la fabrication de tels composés ainsi qu'à des intermédiaires utiles dans de tels procédés.
Bellon Steven
Booker Shon
Cheng Yuan
D'angelo Noel
Dominguez Celia
Amgen Inc.
Gowling Lafleur Henderson Llp
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