Quinolines as type iv phosphodiesterase inhibitors

Details Quinolines as type iv phosphodiesterase inhibitors Quinolines as type iv phosphodiesterase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 215/12 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 215/04 (2006.01) C07D 215/14 (2006.01) C07D 215/18 (2006.01) C07D 401/00 (2006.01) C07D 401/06 (2006.01) C07D 405/04 (2006.01) C07D 413/02 (2006.01) C07D 417/02 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2159603

Optionally 6,8-substituted quinolines of formula (I) wherein: R1 is selected from hydrogen; lower alkyl; cycloalkyl; cycloalkyloxy; cycloalkylamino; cycloalkyl lower alkyl; lower alkoxy; formyl; hydrozy-lower alkyl; carboxyalkyl; optionally substituted aryl, aryloxy, arylamino or aryl lower alkyl; optionally substituted heterocycle, heterocycle- oxy, heterocycle-amino or heterocycle lower alkyl; and R2 is optionally substituted phenyl, or a pharmaceutically acceptable salt or N-oxide thereof, useful as anti-inflammatory agents, immunosuppressive agents, anti-allograft rejection agents, anti-graft-vs-host disease agents, anti-allergic agents (e.g., asthma, rhinitis and atopic dermatitis), bronchodilation agents, anti-autoimmune agents or analgetic agents.

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