Quinolinone derivative and anti-allergic agent with said...

C - Chemistry – Metallurgy – 07 – D

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C07D 215/38 (2006.01) A61K 31/47 (2006.01) C07D 215/22 (2006.01)

Patent

CA 2195031

The present invention offers 7-aminoquinolinone derivatives, physiologically acceptable salts thereof, anti-allergic agents having as an active ingredient a 7- aminoquinolinone derivative or physiologically acceptable salt thereof, and 7-nitroquinolinone derivatives, wherein the 7-aminoquinolinone derivative is expressed by the following general formula (I): (see fig. I) ......(I) wherein R1 is a hydrogen atom or an alkyl group; R2 and R3 are mutually different groups, each of which is selected from among hydrogen atoms, acyl groups, alkyl groups or alkenyl groups; and R4 and R5 are mutually different or identical groups, each of which is selected from among hydrogen atoms, acyl groups, alkyl groups, alkenyl groups or aralkyl groups; and physiologically acceptable salts thereof.

ette invention traite de dérivés de la 7-aminoquinolinone, de sels de 7-aminoquinolinone physiologiquement acceptables, d'agents antiallergiques dont l'un des ingrédients actifs est un dérivé de la 7- aminoquinolinone ou un sel de 7-aminoquinolinone physiologiquement acceptable, et des dérivés de la 7-nitroquinolinone, le dérivé de la 7-aminoquinolinone étant représenté par la formule générale figurant ci-dessous (I): (voir la figure I) ......(I) où R1 est un atome d'hydrogène ou un groupe alkyle, R2 et R3 sont des groupes mutuellement différents, chacun étant choisi parmi des atomes d'hydrogène, des groupes acyles, des groupes alkyles ou des groupes alkényles, et R4 et R5 sont des groupes mutuellement différents ou identiques, chacun étant choisi parmi des atomes d'hydrogène, des groupes acyles, des groupes alkyles, des groupes alkényles ou des groupes aralkyles, et des sels physiologiquement acceptables de ces groupes.

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